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Research Article

CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration

  • Ke Zen mail,

    kzen@nju.edu.cn

    Affiliations: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China, Jiangsu CDC-Nanjing University Joint Institute of Virology, Nanjing, Jiangsu, China

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  • Dan-Qing Liu,

    Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China

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  • Ya-Lan Guo,

    Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China

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  • Chen Wang,

    Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China

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  • Jun Shan,

    Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China

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  • Ming Fang,

    Affiliation: Program of Cell and Molecular Biology, Department of Biology, Georgia State University, Atlanta, Georgia, United States of America

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  • Chen-Yu Zhang,

    Affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China

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  • Yuan Liu

    Affiliation: Program of Cell and Molecular Biology, Department of Biology, Georgia State University, Atlanta, Georgia, United States of America

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  • Published: March 19, 2008
  • DOI: 10.1371/journal.pone.0001826

About the Authors

Ke Zen, Dan-Qing Liu, Ya-Lan Guo, Chen Wang, Jun Shan, Chen-Yu Zhang
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
Ke Zen
Jiangsu CDC-Nanjing University Joint Institute of Virology, Nanjing, Jiangsu, China
Ming Fang, Yuan Liu
Program of Cell and Molecular Biology, Department of Biology, Georgia State University, Atlanta, Georgia, United States of America

Corresponding Author

Email: kzen@nju.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KZ YL CZ. Performed the experiments: KZ DL YG CW JS MF. Analyzed the data: KZ DL YG CW JS CZ. Contributed reagents/materials/analysis tools: YL. Wrote the paper: KZ.