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Research Article

Monomeric Tartrate Resistant Acid Phosphatase Induces Insulin Sensitive Obesity

  • Pernilla Lång,

    Affiliation: Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

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  • Vanessa van Harmelen,

    Affiliation: Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

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  • Mikael Rydén,

    Affiliation: Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

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  • Maria Kaaman,

    Affiliation: Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

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  • Paolo Parini,

    Affiliation: Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

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  • Claes Carneheim,

    Affiliation: Integrative Pharmacology, Biovitrum AB, Stockholm, Sweden

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  • A. Ian Cassady,

    Affiliation: Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia

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  • David A. Hume,

    Affiliations: Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, United Kingdom

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  • Göran Andersson mail,

    *E-mail: goran.andersson@ki.se (GA); peter.arner@ki.se (PA)

    Affiliation: Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

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  • Peter Arner mail

    *E-mail: goran.andersson@ki.se (GA); peter.arner@ki.se (PA)

    Affiliation: Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

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  • Published: March 05, 2008
  • DOI: 10.1371/journal.pone.0001713

About the Authors

Pernilla Lång, Göran Andersson
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
Vanessa van Harmelen, Mikael Rydén, Maria Kaaman, Peter Arner
Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
Paolo Parini
Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
Claes Carneheim
Integrative Pharmacology, Biovitrum AB, Stockholm, Sweden
A. Ian Cassady, David A. Hume
Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
David A. Hume
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GA PL Vv PA. Performed the experiments: PL Vv MR MK PP CC. Analyzed the data: GA PL Vv MR MK PP AC PA CC. Contributed reagents/materials/analysis tools: AC DH. Wrote the paper: GA PL Vv PA DH.