Advertisement
Research Article

Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects

  • Emmanuel S. Onaivi mail,

    *E-mail: OnaiviE@wpunj.edu

    Affiliations: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America, Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Hiroki Ishiguro,

    Affiliations: Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America, Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Japan

    X
  • Jian-Ping Gong,

    Affiliation: Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Sejal Patel,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Paul A. Meozzi,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Lester Myers,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Alex Perchuk,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Zoila Mora,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Patricia A. Tagliaferro,

    Affiliation: Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

    X
  • Eileen Gardner,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Alicia Brusco,

    Affiliation: Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

    X
  • B. Emmanuel Akinshola,

    Affiliation: Department of Pharmacology, Howard University, Washington, D. C., United States of America

    X
  • Bruce Hope,

    Affiliation: Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Javier Lujilde,

    Affiliation: Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

    X
  • Toshiya Inada,

    Affiliation: Chiba Medical Center, Teikyo University, Ichihara, Chiba, Japan

    X
  • Shinya Iwasaki,

    Affiliation: Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • David Macharia,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Lindsey Teasenfitz,

    Affiliation: Department of Biology, William Paterson University, Wayne, New Jersey, United States of America

    X
  • Tadao Arinami,

    Affiliation: Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • George R. Uhl

    Affiliation: Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    X
  • Published: February 20, 2008
  • DOI: 10.1371/journal.pone.0001640

About the Authors

Emmanuel S. Onaivi, Sejal Patel, Paul A. Meozzi, Lester Myers, Alex Perchuk, Zoila Mora, Eileen Gardner, David Macharia, Lindsey Teasenfitz
Department of Biology, William Paterson University, Wayne, New Jersey, United States of America
Emmanuel S. Onaivi, Hiroki Ishiguro, Jian-Ping Gong, Shinya Iwasaki, Tadao Arinami, George R. Uhl
Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America
Hiroki Ishiguro
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Japan
Patricia A. Tagliaferro, Alicia Brusco, Javier Lujilde
Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
B. Emmanuel Akinshola
Department of Pharmacology, Howard University, Washington, D. C., United States of America
Bruce Hope
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse (NID)-National Institutes of Health (NIH), Bethesda, Maryland, United States of America
Toshiya Inada
Chiba Medical Center, Teikyo University, Ichihara, Chiba, Japan

Corresponding Author

Email: OnaiviE@wpunj.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EO HI PT. Performed the experiments: EO HI JG SP PM LM AP ZM JL TI SI DM LT. Analyzed the data: EO HI JG TI. Contributed reagents/materials/analysis tools: GU AB EO HI JG EG BA BH TI TA. Wrote the paper: EO HI.