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Research Article

Phase I Trial of an Alhydrogel Adjuvanted Hepatitis B Core Virus-Like Particle Containing Epitopes of Plasmodium falciparum Circumsporozoite Protein

  • Aric L. Gregson,

    Affiliation: Department of Medicine and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    Current address: Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America,

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  • Giane Oliveira,

    Affiliation: Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, United States of America

    Current address: Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States of America

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  • Caroline Othoro,

    Affiliation: Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, United States of America

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  • J. Mauricio Calvo-Calle,

    Affiliation: Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, United States of America

    Current address: Department of Pathology, University of Massachusetts School of Medicine, Worcester, Massachusetts, United States of America

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  • George B. Thorton,

    Affiliation: Apovia, Inc., San Diego, California, United States of America

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  • Elizabeth Nardin,

    Affiliation: Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, United States of America

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  • Robert Edelman mail

    *E-mail: redelman@medicine.umaryland.edu.

    Affiliation: Department of Medicine and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Published: February 06, 2008
  • DOI: 10.1371/journal.pone.0001556

About the Authors

Aric L. Gregson, Robert Edelman
Department of Medicine and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Giane Oliveira, Caroline Othoro, J. Mauricio Calvo-Calle, Elizabeth Nardin
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, United States of America
George B. Thorton
Apovia, Inc., San Diego, California, United States of America

Corresponding Author

Email: redelman@medicine.umaryland.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EN AG RE GT. Performed the experiments: EN AG RE GO CO JC. Analyzed the data: EN AG RE GO CO JC. Contributed reagents/materials/analysis tools: EN GT. Wrote the paper: EN AG RE.