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Research Article

Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle

  • Rick A. Bright mail,

    To whom correspondence should be addressed. E-mail: rbright@novavax.com (RB); tmr15@pitt.edu (TR)

    Affiliation: Novavax, Inc., Rockville, Maryland, United States of America

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  • Donald M. Carter,

    Affiliation: Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Corey J. Crevar,

    Affiliation: Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Franklin R. Toapanta,

    Affiliation: Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Jonathan D. Steckbeck,

    Affiliation: Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Kelly S. Cole,

    Affiliation: Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Niranjan M. Kumar,

    Affiliation: Novavax, Inc., Rockville, Maryland, United States of America

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  • Peter Pushko,

    Affiliation: Novavax, Inc., Rockville, Maryland, United States of America

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  • Gale Smith,

    Affiliation: Novavax, Inc., Rockville, Maryland, United States of America

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  • Terrence M. Tumpey,

    Affiliation: Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Ted M. Ross mail

    To whom correspondence should be addressed. E-mail: rbright@novavax.com (RB); tmr15@pitt.edu (TR)

    Affiliation: Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: January 30, 2008
  • DOI: 10.1371/journal.pone.0001501

About the Authors

Rick A. Bright, Niranjan M. Kumar, Peter Pushko, Gale Smith
Novavax, Inc., Rockville, Maryland, United States of America
Donald M. Carter, Corey J. Crevar, Franklin R. Toapanta, Jonathan D. Steckbeck, Kelly S. Cole, Ted M. Ross
Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Terrence M. Tumpey
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TR RB KC CC. Performed the experiments: TT PP DC FT JS CC. Analyzed the data: TT TR RB GS DC FT JS KC CC. Contributed reagents/materials/analysis tools: TT RB GS PP NK. Wrote the paper: TR.