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Research Article

Capillary Regeneration in Scleroderma: Stem Cell Therapy Reverses Phenotype?

  • Jo N. Fleming mail,

    To whom correspondence should be addressed. E-mail: flemij@u.washington.edu

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

    X
  • Richard A. Nash,

    Affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • D. O. McLeod,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • David F. Fiorentino,

    Affiliation: Department of Dermatology, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Howard M. Shulman,

    Affiliation: Clinical Research Division, Pathology Section, Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance, Seattle, Washington, United States of America

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  • M. Kari Connolly,

    Affiliation: Department of Medicine, University of California at San Francisco, San Francisco, California, United States of America

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  • Jerry A. Molitor,

    Affiliation: Department of Rheumatology, Virginia Mason Medical Center, Seattle, Washington, United States of America

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  • Gretchen Henstorf,

    Affiliation: Program in Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Robert Lafyatis,

    Affiliation: Rheumatology Section, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • David K. Pritchard,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Lawrence D. Adams,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Daniel E. Furst,

    Affiliation: Department of Rheumatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Stephen M. Schwartz

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Published: January 16, 2008
  • DOI: 10.1371/journal.pone.0001452

About the Authors

Jo N. Fleming, D. O. McLeod, David K. Pritchard, Lawrence D. Adams, Stephen M. Schwartz
Department of Pathology, University of Washington, Seattle, Washington, United States of America
Richard A. Nash
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
David F. Fiorentino
Department of Dermatology, Stanford University School of Medicine, Stanford, California, United States of America
Howard M. Shulman
Clinical Research Division, Pathology Section, Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance, Seattle, Washington, United States of America
M. Kari Connolly
Department of Medicine, University of California at San Francisco, San Francisco, California, United States of America
Jerry A. Molitor
Department of Rheumatology, Virginia Mason Medical Center, Seattle, Washington, United States of America
Gretchen Henstorf
Program in Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Robert Lafyatis
Rheumatology Section, Boston University School of Medicine, Boston, Massachusetts, United States of America
Daniel E. Furst
Department of Rheumatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: flemij@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS JF DF. Performed the experiments: JF DM. Analyzed the data: JF GH HS. Contributed reagents/materials/analysis tools: JF RN DF MC JM GH RL HS. Wrote the paper: SS JF RN JM RL DP LA DF HS.