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Research Article

Y-Chromosome Based Evidence for Pre-Neolithic Origin of the Genetically Homogeneous but Diverse Sardinian Population: Inference for Association Scans

  • Daniela Contu equal contributor,

    equal contributor Contributed equally to this work with: Daniela Contu, Laura Morelli

    Affiliation: Laboratorio di Immunogenetica, Ospedale Microcitemico, Cagliari, Italy

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  • Laura Morelli equal contributor,

    equal contributor Contributed equally to this work with: Daniela Contu, Laura Morelli

    Affiliation: Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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  • Federico Santoni,

    Affiliation: Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy

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  • Jamie W. Foster,

    Affiliation: Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

    Current address: Albert Park, Melbourne, Australia

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  • Paolo Francalacci,

    Affiliation: Dipartimento di Zoologia e Genetica Evoluzionistica, Università di Sassari, Sassari, Italy

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  • Francesco Cucca mail

    To whom correspondence should be addressed. E-mail: fcucca@uniss.it

    Affiliation: Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

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  • Published: January 09, 2008
  • DOI: 10.1371/journal.pone.0001430

About the Authors

Daniela Contu
Laboratorio di Immunogenetica, Ospedale Microcitemico, Cagliari, Italy
Laura Morelli, Jamie W. Foster, Francesco Cucca
Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy
Federico Santoni
Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
Paolo Francalacci
Dipartimento di Zoologia e Genetica Evoluzionistica, Università di Sassari, Sassari, Italy

Corresponding Author

Email: fcucca@uniss.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FC LM DC FS PF. Performed the experiments: LM DC. Analyzed the data: FC LM DC FS. Contributed reagents/materials/analysis tools: FC. Wrote the paper: FC. Other: Designed and supervised the study: FC. Participated in the study design: PF LM DC. Wrote the manuscript: FC. Revised the manuscript: PF LM CD. Assisted in manuscript revision: JF. Developed software to implement data analysis: FS. Participated in analysis of the data: DC. Performed statistical analysis: FS LM. Proposed mode-based estimates in BATWING analysis: FS. Performed marker genotyping: DC. Participated in marker genotyping: LM. Designed figures and tables: LM. Participated in designing figures and tables: DC. Read and approved the final manuscript: DC LM FS JF PF FC.