C-Reactive Protein (CRP) Gene Polymorphisms, CRP Levels, and Risk of Incident Coronary Heart Disease in Two Nested Case-Control Studies

Jennifer K. Pai; Kenneth J. Mukamal; Kathryn M. Rexrode; Eric B. Rimm

doi:10.1371/journal.pone.0001395

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Open Access

Peer-reviewed

Research Article

C-Reactive Protein (CRP) Gene Polymorphisms, CRP Levels, and Risk of Incident Coronary Heart Disease in Two Nested Case-Control Studies

Jennifer K. Pai ,

*To whom correspondence should be addressed. E-mail: jpai@hsph.harvard.edu

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kenneth J. Mukamal,

Affiliation Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Kathryn M. Rexrode,

Affiliation Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Eric B. Rimm

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

C-Reactive Protein (CRP) Gene Polymorphisms, CRP Levels, and Risk of Incident Coronary Heart Disease in Two Nested Case-Control Studies

Jennifer K. Pai,
Kenneth J. Mukamal,
Kathryn M. Rexrode,
Eric B. Rimm

Published: January 2, 2008
https://doi.org/10.1371/journal.pone.0001395

About the Authors

Jennifer K. Pai

*To whom correspondence should be addressed. E-mail: jpai@hsph.harvard.edu

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Kenneth J. Mukamal

Affiliation Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Kathryn M. Rexrode

Affiliation Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Eric B. Rimm

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP KM KR ER. Analyzed the data: JP KM ER. Wrote the paper: JP. Other: Provided statistical support and manuscript editing: KM KR. Provided data collection: KR ER. Provided funding: ER. Provided manuscript writing: ER.

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C-reactive proteins
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Haplotypes
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Single nucleotide polymorphisms
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Cardiovascular disease risk
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Cardiovascular diseases in women
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Coronary heart disease
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Women's health
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Blood plasma
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