Shotgun Lipidomics Identifies a Paired Rule for the Presence of Isomeric Ether Phospholipid Molecular Species

Kui Yang; Zhongdan Zhao; Richard W. Gross; Xianlin Han

doi:10.1371/journal.pone.0001368

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Open Access

Peer-reviewed

Research Article

Shotgun Lipidomics Identifies a Paired Rule for the Presence of Isomeric Ether Phospholipid Molecular Species

Kui Yang,

Affiliation Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Zhongdan Zhao,

Affiliation Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Richard W. Gross,

Affiliations Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Chemistry, Washington University, St. Louis, Missouri, United States of America
⨯
Xianlin Han

*To whom correspondence should be addressed. E-mail: xianlin@wustl.edu

Affiliation Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Shotgun Lipidomics Identifies a Paired Rule for the Presence of Isomeric Ether Phospholipid Molecular Species

Kui Yang,
Zhongdan Zhao,
Richard W. Gross,
Xianlin Han

Published: December 26, 2007
https://doi.org/10.1371/journal.pone.0001368

About the Authors

Kui Yang

Affiliation Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

Zhongdan Zhao

Affiliation Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

Richard W. Gross

Affiliations Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Chemistry, Washington University, St. Louis, Missouri, United States of America

Xianlin Han

*To whom correspondence should be addressed. E-mail: xianlin@wustl.edu

Affiliation Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XH KY RG. Performed the experiments: KY ZZ. Analyzed the data: XH KY. Contributed reagents/materials/analysis tools: XH RG. Wrote the paper: XH KY RG.

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Ethers
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Lipid analysis
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Lipids
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Phospholipids
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Heart
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Mass spectrometers
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Bligh and Dyer extraction
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Mass analysis
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