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Research Article

Involvement of Skeletal Muscle Gene Regulatory Network in Susceptibility to Wound Infection Following Trauma

  • Yiorgos Apidianakis equal contributor,

    equal contributor Contributed equally to this work with: Yiorgos Apidianakis, Michael N. Mindrinos

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriner's Burns Institute, Boston, Massachusetts, United States of America

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  • Michael N. Mindrinos equal contributor,

    equal contributor Contributed equally to this work with: Yiorgos Apidianakis, Michael N. Mindrinos

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Wenzhong Xiao,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • George P. Tegos,

    Affiliation: Department of Dermatology Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Michail I. Papisov,

    Affiliation: Laboratory of Molecular Bioengineering, Division of Nuclear Medicine, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Michael R. Hamblin,

    Affiliation: Department of Dermatology Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Ronald W. Davis,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ronald G. Tompkins,

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriner's Burns Institute, Boston, Massachusetts, United States of America

    X
  • Laurence G. Rahme mail

    To whom correspondence should be addressed. E-mail: rahme@amber.mgh.harvard.edu

    Affiliations: Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shriner's Burns Institute, Boston, Massachusetts, United States of America, Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston Massachusetts, United States of America

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  • Published: December 26, 2007
  • DOI: 10.1371/journal.pone.0001356

About the Authors

Yiorgos Apidianakis, Ronald G. Tompkins, Laurence G. Rahme
Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
Yiorgos Apidianakis, Ronald G. Tompkins, Laurence G. Rahme
Shriner's Burns Institute, Boston, Massachusetts, United States of America
Michael N. Mindrinos, Wenzhong Xiao, Ronald W. Davis
Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America
George P. Tegos, Michael R. Hamblin
Department of Dermatology Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Michail I. Papisov
Laboratory of Molecular Bioengineering, Division of Nuclear Medicine, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Laurence G. Rahme
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston Massachusetts, United States of America

Corresponding Author

Email: rahme@amber.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LR YA MM. Performed the experiments: YA MM GT. Analyzed the data: LR YA MM WX. Contributed reagents/materials/analysis tools: MP MH RT RD. Wrote the paper: LR YA.