Inheritance of an Epigenetic Mark: The CpG DNA Methyltransferase 1 Is Required for De Novo Establishment of a Complex Pattern of Non-CpG Methylation

Valérie Grandjean; Ruken Yaman; François Cuzin; Minoo Rassoulzadegan

doi:10.1371/journal.pone.0001136

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Peer-reviewed

Research Article

Inheritance of an Epigenetic Mark: The CpG DNA Methyltransferase 1 Is Required for De Novo Establishment of a Complex Pattern of Non-CpG Methylation

Valérie Grandjean ,

*To whom correspondence should be addressed. E-mail: grandjea@unice.fr

Affiliations Inserm, U636, Nice, France, Laboratoire de Génétique du Développement Normal et Pathologique, Université de Nice-Sophia Antipolis, Nice, France, Equipe Labellisée Ligue Nationale Contre le Cancer, Nice, France
⨯
Ruken Yaman,

Affiliations Inserm, U636, Nice, France, Laboratoire de Génétique du Développement Normal et Pathologique, Université de Nice-Sophia Antipolis, Nice, France, Equipe Labellisée Ligue Nationale Contre le Cancer, Nice, France
⨯
François Cuzin,

Affiliations Inserm, U636, Nice, France, Laboratoire de Génétique du Développement Normal et Pathologique, Université de Nice-Sophia Antipolis, Nice, France, Equipe Labellisée Ligue Nationale Contre le Cancer, Nice, France
⨯
Minoo Rassoulzadegan

Affiliations Inserm, U636, Nice, France, Laboratoire de Génétique du Développement Normal et Pathologique, Université de Nice-Sophia Antipolis, Nice, France, Equipe Labellisée Ligue Nationale Contre le Cancer, Nice, France
⨯

Inheritance of an Epigenetic Mark: The CpG DNA Methyltransferase 1 Is Required for De Novo Establishment of a Complex Pattern of Non-CpG Methylation

Valérie Grandjean,
Ruken Yaman,
François Cuzin,
Minoo Rassoulzadegan

Published: November 7, 2007
https://doi.org/10.1371/journal.pone.0001136

About the Authors

Valérie Grandjean

*To whom correspondence should be addressed. E-mail: grandjea@unice.fr

Affiliations Inserm, U636, Nice, France, Laboratoire de Génétique du Développement Normal et Pathologique, Université de Nice-Sophia Antipolis, Nice, France, Equipe Labellisée Ligue Nationale Contre le Cancer, Nice, France

Ruken Yaman

François Cuzin

Minoo Rassoulzadegan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MR VG FC. Performed the experiments: VG RY. Analyzed the data: MR VG FC. Wrote the paper: MR VG FC.

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DNA methylation
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Methylation
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Mammalian genomics
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Sperm
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Genetic loci
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Epigenetics
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Cytosine
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Heterozygosity
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