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Research Article

Syk-Mediated Translocation of PI3Kδ to the Leading Edge Controls Lamellipodium Formation and Migration of Leukocytes

  • Jürgen Schymeinsky equal contributor,

    equal contributor Contributed equally to this work with: Jürgen Schymeinsky, Cornelia Then

    Affiliation: Department of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany

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  • Cornelia Then equal contributor,

    equal contributor Contributed equally to this work with: Jürgen Schymeinsky, Cornelia Then

    Affiliation: Department of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany

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  • Anca Sindrilaru,

    Affiliation: Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany

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  • Ronald Gerstl,

    Affiliation: Department of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany

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  • Zoltán Jakus,

    Affiliation: Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary

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  • Victor L. J. Tybulewicz,

    Affiliation: Division of Immune Cell Biology, National Institute for Medical Research, London, United Kingdom

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  • Karin Scharffetter-Kochanek,

    Affiliation: Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany

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  • Barbara Walzog mail

    To whom correspondence should be addressed. E-mail: walzog@lrz.uni-muenchen.de

    Affiliation: Department of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany

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  • Published: November 07, 2007
  • DOI: 10.1371/journal.pone.0001132

About the Authors

Jürgen Schymeinsky, Cornelia Then, Ronald Gerstl, Barbara Walzog
Department of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany
Anca Sindrilaru, Karin Scharffetter-Kochanek
Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany
Zoltán Jakus
Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary
Victor L. J. Tybulewicz
Division of Immune Cell Biology, National Institute for Medical Research, London, United Kingdom

Corresponding Author

Email: walzog@lrz.uni-muenchen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KS JS BW AS. Performed the experiments: JS CT AS. Analyzed the data: KS JS BW CT AS. Contributed reagents/materials/analysis tools: VT RG ZJ. Wrote the paper: JS BW.