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Research Article

The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface

  • Niels Volkmann,

    Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • HongJun Lui,

    Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Larnele Hazelwood,

    Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Kathleen M. Trybus,

    Affiliation: Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, United States of America

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  • Susan Lowey mail,

    To whom correspondence should be addressed. E-mail: Susan.Lowey@uvm.edu (SL); dorit@burnham.org (DH)

    Affiliation: Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, United States of America

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  • Dorit Hanein mail

    To whom correspondence should be addressed. E-mail: Susan.Lowey@uvm.edu (SL); dorit@burnham.org (DH)

    Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Published: November 07, 2007
  • DOI: 10.1371/journal.pone.0001123

About the Authors

Niels Volkmann, HongJun Lui, Larnele Hazelwood, Dorit Hanein
Burnham Institute for Medical Research, La Jolla, California, United States of America
Kathleen M. Trybus, Susan Lowey
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DH NV KT SL. Performed the experiments: LH. Analyzed the data: DH NV HL. Contributed reagents/materials/analysis tools: DH NV KT SL. Wrote the paper: DH NV KT SL.