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Research Article

Ankyrin-B Syndrome: Enhanced Cardiac Function Balanced by Risk of Cardiac Death and Premature Senescence

  • Peter J. Mohler mail,

    To whom correspondence should be addressed. E-mail: peter-mohler@uiowa.edu (PM); v.bennett@cellbio.duke.edu (VB)

    Affiliations: Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America, Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America

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  • Jane A. Healy,

    Affiliations: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Hui Xue,

    Affiliations: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Annibale A. Puca,

    Affiliation: Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico MultiMedica, Milan, Italy

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  • Crystal F. Kline,

    Affiliations: Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America, Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America

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  • R. Rand Allingham,

    Affiliation: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Evangelia G. Kranias,

    Affiliation: Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Howard A. Rockman,

    Affiliations: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Vann Bennett mail

    To whom correspondence should be addressed. E-mail: peter-mohler@uiowa.edu (PM); v.bennett@cellbio.duke.edu (VB)

    Affiliations: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: October 17, 2007
  • DOI: 10.1371/journal.pone.0001051

About the Authors

Peter J. Mohler, Crystal F. Kline
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
Peter J. Mohler, Crystal F. Kline
Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
Howard A. Rockman, Vann Bennett
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America
Jane A. Healy, Vann Bennett
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America
Hui Xue, Howard A. Rockman
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
R. Rand Allingham
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America
Annibale A. Puca
Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico MultiMedica, Milan, Italy
Evangelia G. Kranias
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Jane A. Healy, Hui Xue, Vann Bennett
Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VB AP PM JH HR CK RA. Performed the experiments: VB AP PM JH HX HR CK RA. Analyzed the data: VB EK AP PM JH HX HR CK RA. Contributed reagents/materials/analysis tools: VB EK AP PM JH HX HR CK RA. Wrote the paper: VB EK AP PM JH CK RA. Other: Designed the study: PM. Wrote the first draft of the paper: PM.