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Research Article

Site-Directed Mutations in the C-Terminal Extension of Human αB-Crystallin Affect Chaperone Function and Block Amyloid Fibril Formation

  • Teresa M. Treweek,

    Affiliations: Department of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia, Graduate School of Medicine, University of Wollongong, Wollongong, New South Wales, Australia

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  • Heath Ecroyd,

    Affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, Australia

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  • Danielle M. Williams,

    Affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, Australia

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  • Sarah Meehan,

    Affiliation: The University Chemical Laboratory, University of Cambridge, Cambridge, United Kingdom

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  • John A. Carver,

    Affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, Australia

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  • Mark J. Walker mail

    To whom correspondence should be addressed. E-mail: mwalker@uow.edu.au

    Affiliation: School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia

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  • Published: October 17, 2007
  • DOI: 10.1371/journal.pone.0001046

About the Authors

Teresa M. Treweek
Department of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia
Teresa M. Treweek
Graduate School of Medicine, University of Wollongong, Wollongong, New South Wales, Australia
Heath Ecroyd, Danielle M. Williams, John A. Carver
School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, Australia
Sarah Meehan
The University Chemical Laboratory, University of Cambridge, Cambridge, United Kingdom
Mark J. Walker
School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia

Corresponding Author

Email: mwalker@uow.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MW TT HE SM JC. Performed the experiments: TT HE DW. Analyzed the data: TT HE. Contributed reagents/materials/analysis tools: MW JC. Wrote the paper: MW TT HE SM JC.