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Research Article

Conservation, Variability and the Modeling of Active Protein Kinases

  • James D. R. Knight,

    Affiliations: Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, The University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

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  • Bin Qian,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • David Baker,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • Rashmi Kothary mail

    To whom correspondence should be addressed. E-mail: rkothary@ohri.ca

    Affiliations: Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada, The University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

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  • Published: October 03, 2007
  • DOI: 10.1371/journal.pone.0000982

About the Authors

James D. R. Knight, Rashmi Kothary
Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
James D. R. Knight, Rashmi Kothary
The University of Ottawa Centre for Neuromuscular Disease, Ottawa, Ontario, Canada
James D. R. Knight, Rashmi Kothary
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
Bin Qian, David Baker
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
Rashmi Kothary
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada

Corresponding Author

Email: rkothary@ohri.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JK RK. Performed the experiments: JK BQ. Analyzed the data: JK BQ. Wrote the paper: JK. Other: Developed and implemented the structure prediction method described: DB BQ JK.