About the Authors

Matthew C. T. Hartman

Current address: Department of Chemistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America,

Affiliation Howard Hughes Medical Institute, Department of Molecular Biology, Center for Computational and Integrative Biology, Simches Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Kristopher Josephson

Current address: EMD Serono Research Institute, Rockland, Massachusetts, United States of America

Affiliation Howard Hughes Medical Institute, Department of Molecular Biology, Center for Computational and Integrative Biology, Simches Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Chi-Wang Lin

Affiliation Howard Hughes Medical Institute, Department of Molecular Biology, Center for Computational and Integrative Biology, Simches Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jack W. Szostak

To whom correspondence should be addressed. E-mail: szostak@molbio.mgh.harvard.edu

Affiliation Howard Hughes Medical Institute, Department of Molecular Biology, Center for Computational and Integrative Biology, Simches Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS MH KJ CL. Performed the experiments: MH KJ CL. Analyzed the data: JS MH KJ CL. Wrote the paper: JS MH.