About the Authors

José A. M. Borghans

Affiliations Theoretical Biology/Bioinformatics, Utrecht University, Utrecht, The Netherlands, Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands

Anne Mølgaard

Affiliation Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

Rob J. de Boer

Affiliation Theoretical Biology/Bioinformatics, Utrecht University, Utrecht, The Netherlands

Can Keşmir

To whom correspondence should be addressed. E-mail: c.kesmir@uu.nl

Affiliations Theoretical Biology/Bioinformatics, Utrecht University, Utrecht, The Netherlands, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark, Academic Biomedical Centre, Utrecht University, Utrecht, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: CK AM. Wrote the paper: JB. Other: Performed the bio-informatic analyses: CK. Made the crystal structure analyses: AM. Contributed to the study design: Rd CK JB. Contributed to the interpretation of the data: AM Rd CK JB. Contributed to the writing of the manuscript: AM Rd JB CK.