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Research Article

Primary Role of Functional Ischemia, Quantitative Evidence for the Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy

  • Akihiro Asai,

    Affiliations: Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Nita Sahani,

    Affiliation: Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Masao Kaneki,

    Affiliation: Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Yasuyoshi Ouchi,

    Affiliation: Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • J. A. Jeevendra Martyn,

    Affiliation: Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Shingo Egusa Yasuhara mail

    To whom correspondence should be addressed. E-mail: shingo_yasuhara@yahoo.com

    Affiliation: Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: August 29, 2007
  • DOI: 10.1371/journal.pone.0000806

About the Authors

Akihiro Asai, Nita Sahani, Masao Kaneki, J. A. Jeevendra Martyn, Shingo Egusa Yasuhara
Department of Anesthesiology and Critical Care, Shriners Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Akihiro Asai, Yasuyoshi Ouchi
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Corresponding Author

Email: shingo_yasuhara@yahoo.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SY. Performed the experiments: SY AA. Analyzed the data: SY AA. Contributed reagents/materials/analysis tools: SY NS MK YO JM. Wrote the paper: SY. Other: Financial support: JM. Principal investigator: SY.