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Research Article

Utrophin Up-Regulation by an Artificial Transcription Factor in Transgenic Mice

  • Elisabetta Mattei,

    Affiliations: Istituto di Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche, European Brain Research Institute, Rome, Italy, Italian Association for Cancer Research, Roman Oncogenomic Center, Rome, Italy

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  • Nicoletta Corbi,

    Affiliation: Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Regina Elena Cancer Institute, Rome, Italy

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  • Maria Grazia Di Certo,

    Affiliations: Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy, Istituto di Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche, European Brain Research Institute, Rome, Italy

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  • Georgios Strimpakos,

    Affiliation: Istituto di Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche, European Brain Research Institute, Rome, Italy

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  • Cinzia Severini,

    Affiliation: Istituto di Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche, European Brain Research Institute, Rome, Italy

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  • Annalisa Onori,

    Affiliation: Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Regina Elena Cancer Institute, Rome, Italy

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  • Agata Desantis,

    Affiliations: Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Regina Elena Cancer Institute, Rome, Italy, Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy

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  • Valentina Libri,

    Affiliation: Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Regina Elena Cancer Institute, Rome, Italy

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  • Serena Buontempo,

    Affiliation: Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Regina Elena Cancer Institute, Rome, Italy

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  • Aristide Floridi,

    Affiliations: Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy, Laboratory B, Regina Elena Cancer Institute, Rome, Italy

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  • Maurizio Fanciulli,

    Affiliations: Italian Association for Cancer Research, Roman Oncogenomic Center, Rome, Italy, Laboratory B, Regina Elena Cancer Institute, Rome, Italy

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  • Dilair Baban,

    Affiliation: Department of Physiology, Anatomy and Genetics, Medical Research Council Functional Genetics Unit, University of Oxford, Oxford, United Kingdom

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  • Kay E. Davies,

    Affiliation: Department of Physiology, Anatomy and Genetics, Medical Research Council Functional Genetics Unit, University of Oxford, Oxford, United Kingdom

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  • Claudio Passananti mail

    To whom correspondence should be addressed. E-mail: passananti@ifo.it

    Affiliations: Italian Association for Cancer Research, Roman Oncogenomic Center, Rome, Italy, Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Regina Elena Cancer Institute, Rome, Italy

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  • Published: August 22, 2007
  • DOI: 10.1371/journal.pone.0000774

About the Authors

Elisabetta Mattei, Maria Grazia Di Certo, Georgios Strimpakos, Cinzia Severini
Istituto di Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche, European Brain Research Institute, Rome, Italy
Elisabetta Mattei, Maurizio Fanciulli, Claudio Passananti
Italian Association for Cancer Research, Roman Oncogenomic Center, Rome, Italy
Nicoletta Corbi, Annalisa Onori, Agata Desantis, Valentina Libri, Serena Buontempo, Claudio Passananti
Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Regina Elena Cancer Institute, Rome, Italy
Maria Grazia Di Certo, Agata Desantis, Aristide Floridi
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy
Aristide Floridi, Maurizio Fanciulli
Laboratory B, Regina Elena Cancer Institute, Rome, Italy
Dilair Baban, Kay E. Davies
Department of Physiology, Anatomy and Genetics, Medical Research Council Functional Genetics Unit, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: passananti@ifo.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CP KD. Performed the experiments: CP EM NC MD GS CS AO AD VL SB DB. Analyzed the data: CP EM NC MD CS DB KD. Contributed reagents/materials/analysis tools: AF MF. Wrote the paper: CP EM NC MD.