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Research Article

A Randomised Placebo-Controlled Trial of a Traditional Chinese Herbal Formula in the Treatment of Primary Dysmenorrhoea

  • Lan Lan Liang Yeh mail,

    To whom correspondence should be addressed. E-mail: lanlanliang2@yahoo.com

    Affiliation: Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan

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  • Jah-Yao Liu,

    Affiliation: Department of Obstetrics and Gynaecology, Tri-Service General Hospital of National Defense Medical Centre, Taipei, Taiwan

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  • Kao-Si Lin,

    Affiliation: Department of Chinese Medicine, Tri-Service General Hospital of National Defense Medical Centre, Taipei, Taiwan

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  • Yu-Shen Liu,

    Affiliation: Section of Obstetrics and Gynaecology, Taipei Municipal Hospital Zhongxiao Branch, Taipei, Taiwan

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  • Jeng-Min Chiou,

    Affiliation: Institute of Statistical Science of Academia Sinica, Taipei, Taiwan

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  • Kung-Yee Liang,

    Affiliation: Division of Biostatistics and Bioinformatics, National Health Research Institutes, Zhunan, Taiwan

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  • Te-Feng Tsai,

    Affiliation: Section of Chinese Medicine, Taipei Municipal Hospital Zhongxiao Branch, Taipei, Taiwan

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  • Li-Hsiang Wang,

    Affiliation: Department of Chinese Medicine, Tri-Service General Hospital of National Defense Medical Centre, Taipei, Taiwan

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  • Chiung-Tong Chen,

    Affiliation: Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan

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  • Ching-Yi Huang

    Affiliation: Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan

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  • Published: August 15, 2007
  • DOI: 10.1371/journal.pone.0000719

About the Authors

Lan Lan Liang Yeh, Ching-Yi Huang
Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan
Jah-Yao Liu
Department of Obstetrics and Gynaecology, Tri-Service General Hospital of National Defense Medical Centre, Taipei, Taiwan
Kao-Si Lin, Li-Hsiang Wang
Department of Chinese Medicine, Tri-Service General Hospital of National Defense Medical Centre, Taipei, Taiwan
Yu-Shen Liu
Section of Obstetrics and Gynaecology, Taipei Municipal Hospital Zhongxiao Branch, Taipei, Taiwan
Jeng-Min Chiou
Institute of Statistical Science of Academia Sinica, Taipei, Taiwan
Kung-Yee Liang
Division of Biostatistics and Bioinformatics, National Health Research Institutes, Zhunan, Taiwan
Te-Feng Tsai
Section of Chinese Medicine, Taipei Municipal Hospital Zhongxiao Branch, Taipei, Taiwan
Chiung-Tong Chen
Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan

Corresponding Author

Email: lanlanliang2@yahoo.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LLY. Performed the experiments: LLY. Analyzed the data: LLY J-MC C-YH. Contributed reagents/materials/analysis tools: LLY. Wrote the paper: LLY. Other: Initiated the investigations: LLY. Proposed preliminary study design: LLY. Wrote protocol: LLY. Obtained funding: LLY. Recruited subjects: LLY. Organized the team: LLY. Coordinated study execution: LLY. Contributed to the study design on dosage regimen: LLY J-YL K-SL. Screened pharmaceutical companies and determined the formulation: LLY C-TC. Initiated and developed electronic data capture system: LLY. Collected, managed, and analyzed data: LLY. Had the idea of sealing capsules to mask the aroma: J-YL. Performed Ultrasound examination: J-YL Y-SL. Performed blood draw: J-YL Y-SL. Determined the classification of dysmenorrhoea: J-YL. Prescribed and handed out ibuprofen: J-YL Y-SL. Attended adverse reactions: J-YL K-SL. Revised online diary: J-YL K-SL Y-SL T-FT. Designed repeated measurement analyses: K-YL J-MC. Performed repeated measurement analyses: J-MC. Wrote statistical report: J-MC. Prescribed and handed out the study products: L-HW T-FT. Wrote the report: LLY.