Novel Peptide Sequence (“IQ-tag”) with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging

Kimberly A. Kelly; Jonathan Carson; Jason R. McCarthy; Ralph Weissleder

doi:10.1371/journal.pone.0000665

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Open Access

Peer-reviewed

Research Article

Novel Peptide Sequence (“IQ-tag”) with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging

Kimberly A. Kelly ,

Contributed equally to this work with: Kimberly A. Kelly, Jonathan Carson

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jonathan Carson ,

Contributed equally to this work with: Kimberly A. Kelly, Jonathan Carson

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jason R. McCarthy,

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ralph Weissleder

*To whom correspondence should be addressed. E-mail: weissleder@helix.mgh.harvard.edu

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Novel Peptide Sequence (“IQ-tag”) with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging

Kimberly A. Kelly,
Jonathan Carson,
Jason R. McCarthy,
Ralph Weissleder

Published: July 25, 2007
https://doi.org/10.1371/journal.pone.0000665

About the Authors

Kimberly A. Kelly

Contributed equally to this work with: Kimberly A. Kelly, Jonathan Carson

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Jonathan Carson

Contributed equally to this work with: Kimberly A. Kelly, Jonathan Carson

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Jason R. McCarthy

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Ralph Weissleder

*To whom correspondence should be addressed. E-mail: weissleder@helix.mgh.harvard.edu

Affiliation Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RW KK JC JM. Performed the experiments: KK JC JM. Analyzed the data: RW KK JC JM. Contributed reagents/materials/analysis tools: KK. Wrote the paper: RW.

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