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Research Article

Neural Decision Boundaries for Maximal Information Transmission

  • Tatyana Sharpee mail,

    To whom correspondence should be addressed. E-mail: sharpee@salk.edu

    Affiliation: Crick-Jacobs Center for Theoretical Biology and Laboratory of Computational Neurobiology, The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • William Bialek

    Affiliation: Joseph Henry Laboratories of Physics, Lewis–Sigler Institute for Integrative Genomics, The Princeton Center for Theoretical Physics, Princeton University, Princeton, New Jersey, United States of America

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  • Published: July 25, 2007
  • DOI: 10.1371/journal.pone.0000646

About the Authors

Tatyana Sharpee
Crick-Jacobs Center for Theoretical Biology and Laboratory of Computational Neurobiology, The Salk Institute for Biological Studies, La Jolla, California, United States of America
William Bialek
Joseph Henry Laboratories of Physics, Lewis–Sigler Institute for Integrative Genomics, The Princeton Center for Theoretical Physics, Princeton University, Princeton, New Jersey, United States of America

Corresponding Author

Email: sharpee@salk.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Wrote the paper: WB TS. Other: Derived the general equation for optimal decision boundaries: WB TS. Found and analyzed specific solutions for several example probability distributions: WB TS.