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Research Article

Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization

  • Matthew D. Smith,

    Affiliations: Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Matthew A. Rosenow,

    Affiliations: Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Meitian Wang,

    Affiliation: Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • James P. Allen,

    Affiliation: Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Jack W. Szostak,

    Affiliation: Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • John C. Chaput mail

    To whom correspondence should be addressed. E-mail: john.chaput@asu.edu

    Affiliations: Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Published: May 23, 2007
  • DOI: 10.1371/journal.pone.0000467

About the Authors

Matthew D. Smith, Matthew A. Rosenow, John C. Chaput
Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America
Matthew D. Smith, Matthew A. Rosenow, Meitian Wang, James P. Allen, John C. Chaput
Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America
Jack W. Szostak
Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Corresponding Author

Email: john.chaput@asu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS JC JA. Performed the experiments: JC MS MR MW. Analyzed the data: JC MW JA. Wrote the paper: JS JC JA.