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Research Article

CRE/CREB-Driven Up-Regulation of Gene Expression by Chronic Social Stress in CRE-Luciferase Transgenic Mice: Reversal by Antidepressant Treatment

  • Ulrike Böer mail,

    To whom correspondence should be addressed. E-mail: uboeer1@gwdg.de

    Affiliation: Department of Molecular Pharmacology, University of Göttingen, Göttingen, Germany

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  • Tahseen Alejel,

    Affiliation: Department of Molecular Pharmacology, University of Göttingen, Göttingen, Germany

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  • Stephan Beimesche,

    Affiliation: Department of Molecular Pharmacology, University of Göttingen, Göttingen, Germany

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  • Irmgard Cierny,

    Affiliation: Department of Molecular Pharmacology, University of Göttingen, Göttingen, Germany

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  • Doris Krause,

    Affiliation: Department of Molecular Pharmacology, University of Göttingen, Göttingen, Germany

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  • Willhart Knepel,

    Affiliation: Department of Molecular Pharmacology, University of Göttingen, Göttingen, Germany

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  • Gabriele Flügge

    Affiliations: Laboratory of Clinical Neurobiology, German Primate Center, Göttingen, Germany, DFG Research Center Molecular Physiology of the Brain (CMPB), Göttingen, Germany

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  • Published: May 09, 2007
  • DOI: 10.1371/journal.pone.0000431

About the Authors

Ulrike Böer, Tahseen Alejel, Stephan Beimesche, Irmgard Cierny, Doris Krause, Willhart Knepel
Department of Molecular Pharmacology, University of Göttingen, Göttingen, Germany
Gabriele Flügge
Laboratory of Clinical Neurobiology, German Primate Center, Göttingen, Germany
Gabriele Flügge
DFG Research Center Molecular Physiology of the Brain (CMPB), Göttingen, Germany

Corresponding Author

Email: uboeer1@gwdg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: UB GF WK. Performed the experiments: UB TA SB DK IC. Analyzed the data: UB GF. Wrote the paper: UB GF.