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Research Article

The Origin of Phenotypic Heterogeneity in a Clonal Cell Population In Vitro

  • Daniel Stockholm equal contributor,

    equal contributor Contributed equally to this work with: Daniel Stockholm, Rachid Benchaouir

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Rachid Benchaouir equal contributor,

    equal contributor Contributed equally to this work with: Daniel Stockholm, Rachid Benchaouir

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Julien Picot,

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Philippe Rameau,

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Thi My Anh Neildez,

    Affiliations: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France, Ecole Pratique des Hautes Etudes, Paris, France

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  • Gabriel Landini,

    Affiliation: Oral Pathology Unit, School of Dentistry, The University of Birmingham, Birmingham, England

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  • Corinne Laplace-Builhé,

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Andras Paldi mail

    To whom correspondence should be addressed. E-mail: paldi@genethon.fr

    Affiliations: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France, Ecole Pratique des Hautes Etudes, Paris, France

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  • Published: April 25, 2007
  • DOI: 10.1371/journal.pone.0000394

About the Authors

Daniel Stockholm, Rachid Benchaouir, Julien Picot, Philippe Rameau, Thi My Anh Neildez, Corinne Laplace-Builhé, Andras Paldi
GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France
Thi My Anh Neildez, Andras Paldi
Ecole Pratique des Hautes Etudes, Paris, France
Gabriel Landini
Oral Pathology Unit, School of Dentistry, The University of Birmingham, Birmingham, England

Corresponding Author

Email: paldi@genethon.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AP DS RB TN CL. Performed the experiments: PR DS RB JP TN. Analyzed the data: AP PR DS JP CL GL. Wrote the paper: AP DS CL GL.