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Research Article

Haplotype Association between Haptoglobin (Hp2) and Hp Promoter SNP (A-61C) May Explain Previous Controversy of Haptoglobin and Malaria Protection

  • Sharon E. Cox mail,

    To whom correspondence should be addressed. E-mail: Sharon.cox@lshtm.ac.uk

    Affiliation: Medical Research Council (MRC) International Nutrition Group, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kindgom

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  • Conor Doherty,

    Affiliation: Medical Research Council (MRC) Keneba, MRC Laboratories, The Gambia

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  • Sarah H. Atkinson,

    Affiliations: Medical Research Council (MRC) International Nutrition Group, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kindgom, Medical Research Council (MRC) Keneba, MRC Laboratories, The Gambia

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  • Chidi V. Nweneka,

    Affiliation: Medical Research Council (MRC) Keneba, MRC Laboratories, The Gambia

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  • Anthony J.C. Fulford,

    Affiliation: Medical Research Council (MRC) International Nutrition Group, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kindgom

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  • Hala Ghattas,

    Affiliation: Medical Research Council (MRC) International Nutrition Group, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kindgom

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  • Kirk A. Rockett,

    Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

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  • Dominic P. Kwiatkowski,

    Affiliation: Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

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  • Andrew M. Prentice

    Affiliation: Medical Research Council (MRC) International Nutrition Group, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kindgom

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  • Published: April 11, 2007
  • DOI: 10.1371/journal.pone.0000362

About the Authors

Sharon E. Cox, Sarah H. Atkinson, Anthony J.C. Fulford, Hala Ghattas, Andrew M. Prentice
Medical Research Council (MRC) International Nutrition Group, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kindgom
Conor Doherty, Sarah H. Atkinson, Chidi V. Nweneka
Medical Research Council (MRC) Keneba, MRC Laboratories, The Gambia
Kirk A. Rockett, Dominic P. Kwiatkowski
Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

Corresponding Author

Email: Sharon.cox@lshtm.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AP SA SC CD. Performed the experiments: SC CD CN HG. Analyzed the data: AF KR SC. Contributed reagents/materials/analysis tools: DK KR. Wrote the paper: DK AP AF KR SC CD CN HG.