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Research Article

Modular Mass Spectrometric Tool for Analysis of Composition and Phosphorylation of Protein Complexes

  • Justin D. Blethrow,

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America

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  • Chao Tang,

    Affiliation: XProteo Inc, New York, New York, United States of America

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  • Changhui Deng,

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Andrew N. Krutchinsky mail

    To whom correspondence should be addressed. E-mail: krutcha@picasso.ucsf.edu

    Affiliation: Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Published: April 04, 2007
  • DOI: 10.1371/journal.pone.0000358

About the Authors

Justin D. Blethrow
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
Chao Tang
XProteo Inc, New York, New York, United States of America
Changhui Deng, Andrew N. Krutchinsky
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: krutcha@picasso.ucsf.edu

Competing Interests

The authors of the article, except AK, have no competing financial interests. AK declares a competing financial interest. ThermoElectron and Perkin Elmer license the rights to produce some parts of the MALDI interfaces for vMALDI-IT and prOTOF mass spectrometers. AK is a co-author of several patents covering these parts.

Author Contributions

Conceived and designed the experiments: AK. Performed the experiments: AK JB. Analyzed the data: AK JB. Contributed reagents/materials/analysis tools: AK JB CD. Wrote the paper: AK JB. Other: Produced XProteo search engine for identification of proteins: CT.