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Research Article

Protection of Visual Functions by Human Neural Progenitors in a Rat Model of Retinal Disease

  • David M. Gamm mail,

    To whom correspondence should be addressed. E-mail: dgamm@wisc.edu

    Affiliations: Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America, Waisman Center Stem Cell Research Program, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Shaomei Wang,

    Affiliations: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America, Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon, United States of America

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  • Bin Lu,

    Affiliations: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America, Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon, United States of America

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  • Sergei Girman,

    Affiliations: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America, Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon, United States of America

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  • Toby Holmes,

    Affiliation: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America

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  • Nicholas Bischoff,

    Affiliation: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America

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  • Rebecca L. Shearer,

    Affiliation: Waisman Center Stem Cell Research Program, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Yves Sauvé,

    Affiliations: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America, Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada

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  • Elizabeth Capowski,

    Affiliation: Waisman Center Stem Cell Research Program, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Clive N. Svendsen,

    Affiliations: Departments of Anatomy and Neurology, University of Wisconsin, Madison, Wisconsin, United States of America, Waisman Center Stem Cell Research Program, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Raymond D. Lund

    Affiliations: Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America, Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon, United States of America

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  • Published: March 28, 2007
  • DOI: 10.1371/journal.pone.0000338

About the Authors

David M. Gamm
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
Clive N. Svendsen
Departments of Anatomy and Neurology, University of Wisconsin, Madison, Wisconsin, United States of America
David M. Gamm, Rebecca L. Shearer, Elizabeth Capowski, Clive N. Svendsen
Waisman Center Stem Cell Research Program, University of Wisconsin, Madison, Wisconsin, United States of America
Shaomei Wang, Bin Lu, Sergei Girman, Toby Holmes, Nicholas Bischoff, Yves Sauvé, Raymond D. Lund
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America
Shaomei Wang, Bin Lu, Sergei Girman, Raymond D. Lund
Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon, United States of America
Yves Sauvé
Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada

Corresponding Author

Email: dgamm@wisc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CS YS DG SW SG RL. Performed the experiments: YS DG TH RS EC SW BL SG NB. Analyzed the data: YS DG TH RS EC SW BL SG NB RL. Contributed reagents/materials/analysis tools: CS YS DG EC SW RL. Wrote the paper: DG.