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Research Article

Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection

  • Marylyn M. Addo equal contributor,

    equal contributor Contributed equally to this work with: Marylyn M. Addo, Rika Draenert

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Rika Draenert equal contributor,

    equal contributor Contributed equally to this work with: Marylyn M. Addo, Rika Draenert

    Affiliation: Howard Hughes Medical Institute, Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Almas Rathod,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Cori L. Verrill,

    Affiliation: Howard Hughes Medical Institute, Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Benjamin T. Davis,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Rajesh T. Gandhi,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Gregory K. Robbins,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Nesli O. Basgoz,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • David R. Stone,

    Affiliation: Lemuel Shattuck Hospital, Boston, Massachusetts, United States of America

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  • Daniel E. Cohen,

    Affiliation: Fenway Community Health Center, Boston, Massachusetts, United States of America

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  • Mary N. Johnston,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Theresa Flynn,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Alysse G. Wurcel,

    Affiliations: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America, Lemuel Shattuck Hospital, Boston, Massachusetts, United States of America

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  • Eric S. Rosenberg,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Marcus Altfeld,

    Affiliation: Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Bruce D. Walker mail

    To whom correspondence should be addressed. E-mail: Bwalker@partners.org

    Affiliation: Howard Hughes Medical Institute, Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America

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  • Published: March 28, 2007
  • DOI: 10.1371/journal.pone.0000321

About the Authors

Marylyn M. Addo, Almas Rathod, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld
Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America
Rika Draenert, Cori L. Verrill, Bruce D. Walker
Howard Hughes Medical Institute, Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School Division of AIDS, Boston, Massachusetts, United States of America
David R. Stone, Alysse G. Wurcel
Lemuel Shattuck Hospital, Boston, Massachusetts, United States of America
Daniel E. Cohen
Fenway Community Health Center, Boston, Massachusetts, United States of America

Corresponding Author

Email: Bwalker@partners.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BW MA MA MJ RG RD ER DS AW BD GR DC BD NB TF. Performed the experiments: MA RD AR CV. Analyzed the data: BW MA MA RD AR CV. Contributed reagents/materials/analysis tools: BW MJ RG ER DS AW BD GR DC BD NB TF. Wrote the paper: BW MA MA RD.