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Research Article

LPS Responsiveness and Neutrophil Chemotaxis In Vivo Require PMN MMP-8 Activity

  • Angus M. Tester equal contributor,

    equal contributor Contributed equally to this work with: Angus M. Tester, Jennifer H. Cox

    Affiliation: University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Jennifer H. Cox equal contributor,

    equal contributor Contributed equally to this work with: Angus M. Tester, Jennifer H. Cox

    Affiliation: University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Andrea R. Connor,

    Affiliation: University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Amanda E. Starr,

    Affiliation: University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Richard A. Dean,

    Affiliation: University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Xose S. Puente,

    Affiliation: Department Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain

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  • Carlos López-Otín,

    Affiliation: Department Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain

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  • Christopher M. Overall mail

    To whom correspondence should be addressed. E-mail: chris.overall@ubc.ca

    Affiliation: University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: March 21, 2007
  • DOI: 10.1371/journal.pone.0000312

About the Authors

Angus M. Tester, Jennifer H. Cox, Andrea R. Connor, Amanda E. Starr, Richard A. Dean, Christopher M. Overall
University of British Columbia Centre for Blood Research, Departments of Oral Biological and Medical Sciences, and Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
Xose S. Puente, Carlos López-Otín
Department Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain

Corresponding Author

Email: chris.overall@ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CL CO XP. Performed the experiments: AT JC AC AS RD. Analyzed the data: AT JC. Contributed reagents/materials/analysis tools: CL XP. Wrote the paper: CO AT JC.