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Research Article

Ligand Bound β1 Integrins Inhibit Procaspase-8 for Mediating Cell Adhesion-Mediated Drug and Radiation Resistance in Human Leukemia Cells

  • Doris Estrugo equal contributor,

    equal contributor Contributed equally to this work with: Doris Estrugo, Alexander Fischer

    Affiliation: Bundeswehr Institute of Radiobiology, Munich, Germany

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  • Alexander Fischer equal contributor,

    equal contributor Contributed equally to this work with: Doris Estrugo, Alexander Fischer

    Affiliation: Bundeswehr Institute of Radiobiology, Munich, Germany

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  • Franziska Hess,

    Affiliation: Bundeswehr Institute of Radiobiology, Munich, Germany

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  • Harry Scherthan,

    Affiliation: Bundeswehr Institute of Radiobiology, Munich, Germany

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  • Claus Belka,

    Affiliation: Department of Radiation Oncology, University Tübingen, Tübingen, Germany

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  • Nils Cordes mail

    To whom correspondence should be addressed. E-mail: Nils.Cordes@Oncoray.de

    Affiliations: OncoRay–Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Dresden, Germany, Bundeswehr Institute of Radiobiology, Munich, Germany

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  • Published: March 07, 2007
  • DOI: 10.1371/journal.pone.0000269

About the Authors

Nils Cordes
OncoRay–Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Dresden, Germany
Doris Estrugo, Alexander Fischer, Franziska Hess, Harry Scherthan, Nils Cordes
Bundeswehr Institute of Radiobiology, Munich, Germany
Claus Belka
Department of Radiation Oncology, University Tübingen, Tübingen, Germany

Corresponding Author

Email: Nils.Cordes@Oncoray.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NC. Performed the experiments: NC DE AF FH. Analyzed the data: NC DE AF FH. Contributed reagents/materials/analysis tools: HS CB. Wrote the paper: HS NC CB.