Increased Anxiety-Like Behavior and Enhanced Synaptic Efficacy in the Amygdala of GluR5 Knockout Mice

Long-Jun Wu; Shanelle W. Ko; Hiroki Toyoda; Ming-Gao Zhao; Hui Xu; Kunjumon I. Vadakkan; Ming Ren; Eva Knifed; Fanny Shum; Jessica Quan; Xue-Han Zhang; Min Zhuo

doi:10.1371/journal.pone.0000167

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Peer-reviewed

Research Article

Increased Anxiety-Like Behavior and Enhanced Synaptic Efficacy in the Amygdala of GluR5 Knockout Mice

Long-Jun Wu ,

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Shanelle W. Ko ,

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Hiroki Toyoda ,

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Ming-Gao Zhao ,

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Hui Xu,

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Kunjumon I. Vadakkan,

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Ming Ren,

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Eva Knifed,

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Fanny Shum,

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Jessica Quan,

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Xue-Han Zhang,

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯
Min Zhuo

*To whom correspondence should be addressed. E-mail: min.zhuo@utoronto.ca

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
⨯

Increased Anxiety-Like Behavior and Enhanced Synaptic Efficacy in the Amygdala of GluR5 Knockout Mice

Long-Jun Wu,
Shanelle W. Ko,
Hiroki Toyoda,
Ming-Gao Zhao,
Hui Xu,
Kunjumon I. Vadakkan,
Ming Ren,
Eva Knifed,
Fanny Shum,
Jessica Quan

Published: January 24, 2007
https://doi.org/10.1371/journal.pone.0000167

About the Authors

Long-Jun Wu

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Shanelle W. Ko

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Hiroki Toyoda

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Ming-Gao Zhao

Contributed equally to this work with: Long-Jun Wu, Shanelle W. Ko, Hiroki Toyoda, Ming-Gao Zhao

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Hui Xu

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Kunjumon I. Vadakkan

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Ming Ren

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Eva Knifed

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Fanny Shum

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Jessica Quan

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Xue-Han Zhang

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Min Zhuo

*To whom correspondence should be addressed. E-mail: min.zhuo@utoronto.ca

Affiliation Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MZ SK LW LW. Performed the experiments: SK LW LW HT MZ HX KV EK FS JQ XZ MR. Analyzed the data: SK LW LW HT MZ HX KV EK FS JQ XZ. Contributed reagents/materials/analysis tools: MZ. Wrote the paper: SK LW LW.

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