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Research Article

NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

  • Hanoch Kaphzan,

    Affiliation: Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel

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  • Kenneth J. O'Riordan,

    Affiliation: Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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  • Kile P. Mangan,

    Affiliation: Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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  • Jonathan M. Levenson,

    Affiliation: Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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  • Kobi Rosenblum mail

    To whom correspondence should be addressed. E-mail: kobir@psy.haifa.ac.il

    Affiliation: Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel

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  • Published: December 27, 2006
  • DOI: 10.1371/journal.pone.0000138

About the Authors

Hanoch Kaphzan, Kobi Rosenblum
Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel
Kenneth J. O'Riordan, Kile P. Mangan, Jonathan M. Levenson
Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Corresponding Author

Email: kobir@psy.haifa.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KR HK JL. Performed the experiments: HK KO KM. Analyzed the data: KR HK JL. Wrote the paper: KR HK.