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Research Article

Analysis of In-Vivo LacR-Mediated Gene Repression Based on the Mechanics of DNA Looping

  • Yongli Zhang mail,

    To whom correspondence should be addressed. E-mail: sdlevene@utdallas.edu

    Affiliation: Departments of Chemistry and Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Abbye E. McEwen,

    Affiliation: Institute of Biomedical Sciences and Technology, University of Texas at Dallas, Richardson, Texas, United States of America

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  • Donald M. Crothers,

    Affiliation: Departments of Chemistry and Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Stephen D. Levene mail

    To whom correspondence should be addressed. E-mail: sdlevene@utdallas.edu

    Affiliations: Institute of Biomedical Sciences and Technology, University of Texas at Dallas, Richardson, Texas, United States of America, Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America

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  • Published: December 27, 2006
  • DOI: 10.1371/journal.pone.0000136

About the Authors

Yongli Zhang, Donald M. Crothers
Departments of Chemistry and Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Abbye E. McEwen, Stephen D. Levene
Institute of Biomedical Sciences and Technology, University of Texas at Dallas, Richardson, Texas, United States of America
Stephen D. Levene
Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America

Corresponding Author

Email: sdlevene@utdallas.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DC SL YZ. Performed the experiments: SL YZ AM. Analyzed the data: SL YZ AM. Contributed reagents/materials/analysis tools: YZ. Wrote the paper: SL YZ.