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Research Article

Neurovirulent Vaccine-Derived Polioviruses in Sewage from Highly Immune Populations

  • Lester M. Shulman mail,

    To whom correspondence should be addressed. E-mail: cvlsheba@netvision.net.il

    Affiliation: Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel

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  • Yossi Manor,

    Affiliation: Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel

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  • Danit Sofer,

    Affiliation: Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel

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  • Rachel Handsher,

    Affiliation: Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel

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  • Tiberio Swartz,

    Affiliation: Israel Center for Disease Control, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel

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  • Francis Delpeyroux,

    Affiliation: Unit of Molecular Prevention and Therapy of Human Diseases, Centre National de la Recherche Scientifique FRE 2849, Pasteur Institute, Paris, France

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  • Ella Mendelson

    Affiliations: Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000069

About the Authors

Lester M. Shulman, Yossi Manor, Danit Sofer, Rachel Handsher, Ella Mendelson
Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel
Tiberio Swartz
Israel Center for Disease Control, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer, Israel
Francis Delpeyroux
Unit of Molecular Prevention and Therapy of Human Diseases, Centre National de la Recherche Scientifique FRE 2849, Pasteur Institute, Paris, France
Ella Mendelson
Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel

Corresponding Author

Email: cvlsheba@netvision.net.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LS YM DS RH TS FD EM. Performed the experiments: LS YM DS RH FD. Analyzed the data: LS YM DS RH TS FD EM. Contributed reagents/materials/analysis tools: LS YM DS FD. Wrote the paper: LS. Other: Coordinated study: LS. Coordinated the supplementary environmental surveillance for poliovirus and NPEV: YM. Responsible for immunological characterization of VDPV, conceived and carried out the program for determination of the immunological response of different cohorts to VDPV: DS RH TS. Coordinated and carried out neurovirulence testing of VDPV: FD. Assisted in the overall coordination of the study and the critical review of the manuscript: EM.