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Research Article

Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution

  • Hendrik P.J. Bonarius,

    Affiliation: Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

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  • Frank Baas,

    Affiliation: Department of Neurogenetics, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

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  • Ester B.M. Remmerswaal,

    Affiliation: Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

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  • René A.W. van Lier,

    Affiliation: Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

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  • Ineke J.M. ten Berge,

    Affiliation: Division of Nephrology, Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

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  • Paul P. Tak,

    Affiliation: Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

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  • Niek de Vries mail

    To whom correspondence should be addressed. E-mail: Niek.deVries@amc.uva.nl

    Affiliation: Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000055

About the Authors

Hendrik P.J. Bonarius, Paul P. Tak, Niek de Vries
Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
Frank Baas
Department of Neurogenetics, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
Ester B.M. Remmerswaal, René A.W. van Lier
Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands
Ineke J.M. ten Berge
Division of Nephrology, Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

Corresponding Author

Email: Niek.deVries@amc.uva.nl

Competing Interests

The AMC at the University of Amsterdam, the employer of all authors, filed for a patent application listing N.V. as inventor. In case the system becomes profitable, personal revenues are maximized at €50.000 a year; the department may receive up to 10% of the financial rewards. Neither the AMC nor the transfer office were involved in the conception, editing or the decision to submit the manuscript.

Author Contributions

Conceived and designed the experiments: PT RV Nd HB FB ER It. Performed the experiments: Nd HB It. Analyzed the data: PT RV Nd HB FB It. Contributed reagents/materials/analysis tools: PT RV HB FB ER It. Wrote the paper: PT RV Nd HB FB ER It.