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Research Article

Fine Tuning of Globin Gene Expression by DNA Methylation

  • Alon Goren,

    Affiliation: Department of Cellular Biochemistry and Human Genetics, Hebrew University, Jerusalem, Israel

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  • Giora Simchen,

    Affiliation: Department of Genetics, Hebrew University, Jerusalem, Israel

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  • Eitan Fibach,

    Affiliation: Department of Hematology, Hebrew University, Jerusalem, Israel

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  • Piroska E. Szabo,

    Affiliation: Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America

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  • Keiji Tanimoto,

    Affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan

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  • Lyubomira Chakalova,

    Affiliation: Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, United Kingdom

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  • Gerd P. Pfeifer,

    Affiliation: Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America

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  • Peter J. Fraser,

    Affiliation: Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, United Kingdom

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  • James D. Engel,

    Affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Howard Cedar mail

    To whom correspondence should be addressed. E-mail: cedar@md.huji.ac.il

    Affiliation: Department of Cellular Biochemistry and Human Genetics, Hebrew University, Jerusalem, Israel

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000046

About the Authors

Alon Goren, Howard Cedar
Department of Cellular Biochemistry and Human Genetics, Hebrew University, Jerusalem, Israel
Giora Simchen
Department of Genetics, Hebrew University, Jerusalem, Israel
Eitan Fibach
Department of Hematology, Hebrew University, Jerusalem, Israel
Piroska E. Szabo, Gerd P. Pfeifer
Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America
Keiji Tanimoto
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
Lyubomira Chakalova, Peter J. Fraser
Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, United Kingdom
James D. Engel
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: cedar@md.huji.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HC AG. Performed the experiments: AG PS. Analyzed the data: AG PS. Contributed reagents/materials/analysis tools: JE PF GS JE EF PS KT LC GP. Wrote the paper: HC AG.