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Research Article

Long-Term Persistence of Robust Antibody and Cytotoxic T Cell Responses in Recovered Patients Infected with SARS Coronavirus

  • Taisheng Li mail,

    To whom correspondence should be addressed. E-mail: litsh@263.net (TL); lzhang07@hotmail.com (LZ)

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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  • Jing Xie,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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  • Yuxian He,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America

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  • Hongwei Fan,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    X
  • Laurence Baril,

    Affiliation: Emerging Diseases Epidemiology Unit, Institute Pasteur, Paris, France

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  • Zhifeng Qiu,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    X
  • Yang Han,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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  • Wenbing Xu,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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  • Weihong Zhang,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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  • Hui You,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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  • Yanling Zuo,

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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  • Qing Fang,

    Affiliation: Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America

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  • Jian Yu,

    Affiliation: Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America

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  • Zhiwei Chen,

    Affiliation: Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America

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  • Linqi Zhang mail

    To whom correspondence should be addressed. E-mail: litsh@263.net (TL); lzhang07@hotmail.com (LZ)

    Affiliations: Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000024

About the Authors

Taisheng Li, Jing Xie, Yuxian He, Hongwei Fan, Zhifeng Qiu, Yang Han, Wenbing Xu, Weihong Zhang, Hui You, Yanling Zuo, Linqi Zhang
Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Taisheng Li, Jing Xie, Yuxian He, Hongwei Fan, Zhifeng Qiu, Yang Han, Wenbing Xu, Weihong Zhang, Hui You, Yanling Zuo, Linqi Zhang
Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yuxian He
Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America
Laurence Baril
Emerging Diseases Epidemiology Unit, Institute Pasteur, Paris, France
Qing Fang, Jian Yu, Zhiwei Chen, Linqi Zhang
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZC LZ TL JX YH LB. Performed the experiments: ZC LZ QF TL JX YH HF ZQ YH WX WZ HY YZ JY. Analyzed the data: ZC LZ QF TL JX HF LB ZQ YH WX WZ HY YZ JY. Contributed reagents/materials/analysis tools: LZ. Wrote the paper: LZ