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Research Article

Short and Long-Term Effects of hVEGF-A165 in Cre-Activated Transgenic Mice

  • Pia Leppänen,

    Affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland

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  • Ivana Kholová,

    Affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland

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  • Anssi J. Mähönen,

    Affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland

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  • Kari Airenne,

    Affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland

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  • Suvi Koota,

    Affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland

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  • Hannu Mansukoski,

    Affiliation: Technical University of Dresden, Dresden, Germany

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  • Johanna Närväinen,

    Affiliation: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

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  • Maria Wirzenius,

    Affiliation: Molecular/Cancer Biology Laboratory, Biomedicum, University of Helsinki, Helsinki, Finland

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  • Leena Alhonen,

    Affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland

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  • Juhani Jänne,

    Affiliation: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland

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  • Kari Alitalo,

    Affiliation: Molecular/Cancer Biology Laboratory, Biomedicum, University of Helsinki, Helsinki, Finland

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  • Seppo Ylä-Herttuala mail

    To whom correspondence should be addressed. E-mail: Seppo.Ylaherttuala@uku.fi

    Affiliations: Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland, Department of Medicine and the Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000013

About the Authors

Pia Leppänen, Ivana Kholová, Anssi J. Mähönen, Kari Airenne, Suvi Koota, Leena Alhonen, Juhani Jänne, Seppo Ylä-Herttuala
Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland
Hannu Mansukoski
Technical University of Dresden, Dresden, Germany
Johanna Närväinen
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Maria Wirzenius, Kari Alitalo
Molecular/Cancer Biology Laboratory, Biomedicum, University of Helsinki, Helsinki, Finland
Seppo Ylä-Herttuala
Department of Medicine and the Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland

Corresponding Author

Email: Seppo.Ylaherttuala@uku.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SY PL KA JJ. Performed the experiments: IK AM SK HM JN. Analyzed the data: SY PL IK AM JN. Contributed reagents/materials/analysis tools: KA MW LA. Wrote the paper: SY PL IK AM KA