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Research Article

Impact of Cyclooxygenase Inhibitors in the Women's Health Initiative Hormone Trials: Secondary Analysis of a Randomized Trial

  • Judith Hsia mail,

    To whom correspondence should be addressed. E-mail: jhsia@mfa.gwu.edu

    Affiliation: Department of Medicine, George Washington University, Washington, D. C., United States of America

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  • JoAnn E Manson,

    Affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lewis Kuller,

    Affiliation: Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Mary Pettinger,

    Affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • John H Choe,

    Affiliation: Department of Medicine, University of Washington, Seattle, Washington, United States of America

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  • Robert D Langer,

    Affiliation: Department of Family Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Marian Limacher,

    Affiliation: Department of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Albert Oberman,

    Affiliation: Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama, United States of America

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  • Judith Ockene,

    Affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Mary Jo O'Sullivan,

    Affiliation: Department of Obstetrics and Gynecology, University of Miami, Miami, Florida, United States of America

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  • Jennifer G Robinson,

    Affiliation: Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America

    X
  • for the Women's Health Initiative Research

About the Authors

Judith Hsia
Department of Medicine, George Washington University, Washington, D. C., United States of America
JoAnn E Manson
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Lewis Kuller
Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America
Mary Pettinger
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
John H Choe
Department of Medicine, University of Washington, Seattle, Washington, United States of America
Robert D Langer
Department of Family Medicine, University of California San Diego, La Jolla, California, United States of America
Marian Limacher
Department of Medicine, University of Florida, Gainesville, Florida, United States of America
Albert Oberman
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama, United States of America
Judith Ockene
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Mary Jo O'Sullivan
Department of Obstetrics and Gynecology, University of Miami, Miami, Florida, United States of America
Jennifer G Robinson
Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Corresponding Author

Email: jhsia@mfa.gwu.edu

Competing Interests

JGR has received grants from Abbott, Andrx Labs, Astra-Zeneca, Atherogenics, Bristol-Myers Squibb, GlaxoSmithKline, Hoffman La Roche, Merck, Pfizer, Procter and Gamble, Sanofi-Aventis, Schering-Plough, Sankyo, Takeda, and Wyeth Ayerst; has received speaker honoraria from Bristol-Myers Squibb, Merck, and Pfizer; and is consultant for Bristol-Myers Squibb, Merck, Pfizer, and Proliant. JH, JEM, LK, MP, JHC, RDL, ML, AO, JO, and MJO have declared that no competing interests exist.

Author Contributions

JEM and AO designed the study. RDL helped design the forms used for data capture and supervised data capture at one of the clinical centers for the study. JH, JEM, RDL, ML, AO, JO, MJO, and JGR enrolled patients. JEM RDL, ML, AO, JO, and MJO collected data or did experiments. ML is the lead investigator for the Women's Health Initiative clinical center at the University of Florida and was responsible for the entry, data submission, and follow-up of over 1,000 women enrolled in either of the two Women's Health Initiative hormone trials. JH, LK, and MP analyzed the data. MJO reviewed the data. JH, JEM, LK, MP, JHC, RDL, ML, AO, JO, MJO, and JGR contributed to the writing of the paper.