About the Authors

Helena Tossavainen

Affiliation Program in Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Helsinki, Finland

Sampo Kukkurainen

Affiliations Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, Fimlab Laboratories, Tampere, Finland

Juha A. E. Määttä

Affiliations Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, BioMediTech, Tampere, Finland, Fimlab Laboratories, Tampere, Finland

Niklas Kähkönen

Affiliations Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, BioMediTech, Tampere, Finland

Tero Pihlajamaa

Affiliation Program in Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Helsinki, Finland

Vesa P. Hytönen

Affiliations Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, BioMediTech, Tampere, Finland, Fimlab Laboratories, Tampere, Finland

Markku S. Kulomaa

Affiliations Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland, BioMediTech, Tampere, Finland

Perttu Permi

Perttu.Permi@helsinki.fi

Affiliation Program in Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Helsinki, Finland

Competing Interests

SK, JAEM, NK, VPH and MSK are employed by BioMediTech and/or Fimlab Laboratories, and that Orion Diagnostica has a patent on Chimeric Avidin (patent numbers EP1676858, US7268216), this does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HT SK JAEM NK TP VPH MSK PP. Performed the experiments: HT SK NK TP VPH PP. Analyzed the data: HT SK NK VPH PP. Contributed to the writing of the manuscript: HT SK NK TP VPH PP.