About the Authors

Nicolas Mercado

Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

Yasuo Kizawa

Affiliation Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

Keitaro Ueda

Affiliation Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

Yeping Xiong

Affiliation Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

Genki Kimura

Affiliation Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

Audric Moses

Affiliation Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

Jonathan M. Curtis

Affiliation Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

Kazuhiro Ito

Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

Peter J. Barnes

p.j.barnes@imperial.ac.uk

Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

Competing Interests

Co-author Dr. Kazuhiro Ito is a PLOS ONE Editorial Board member and this work was funded by Daiichi Sankyo. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NM YX YK KI. Performed the experiments: NM GK AM JC KI KU. Analyzed the data: NM YK KI. Contributed reagents/materials/analysis tools: GK JC KI PB. Wrote the paper: NM KI PB.