About the Authors

Mei Li

Affiliation Central Laboratory, The Second Hospital of Dalian Medical University, Dalian, PR China

Qiuping Zhang

Affiliation Department of Pathology, The First Hospital of Dalian Medical University, Dalian, PR China

Lina Liu

Affiliation Department of Internal Medicine, The First Hospital of Dalian Medical University, Dalian, PR China

Weipeng Lu

Affiliation Central Laboratory, The Second Hospital of Dalian Medical University, Dalian, PR China

Hong Wei

Affiliation Central Laboratory, The Second Hospital of Dalian Medical University, Dalian, PR China

Rachel W. Li

Affiliation Medical School, The Australian Medical University, Canberra, Australia

Shen Lu

lvshen1956@126.com

Affiliation Central Laboratory, The Second Hospital of Dalian Medical University, Dalian, PR China

Competing Interests

This work was supported by the National Nature Science Funds in China (Fund No. 81071805) and Dalian Merricon Gene Diagnosis Technology Co., Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ML SL. Performed the experiments: ML WL HW. Analyzed the data: ML SL. Contributed reagents/materials/analysis tools: ML QZ LL SL. Wrote the manuscript: ML SL RWL.