Vaccination with Single Chain Antigen Receptors for Islet-Derived Peptides Presented on I-Ag7 Delays Diabetes in NOD Mice by Inducing Anergy in Self-Reactive T-Cells

Werner Gurr; Margaret Shaw; Raimund I. Herzog; Yanxia Li; Robert Sherwin

doi:10.1371/journal.pone.0069464

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Peer-reviewed

Research Article

Vaccination with Single Chain Antigen Receptors for Islet-Derived Peptides Presented on I-A^g7 Delays Diabetes in NOD Mice by Inducing Anergy in Self-Reactive T-Cells

Werner Gurr ,

* E-mail: werner.gurr@yale.edu

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Margaret Shaw,

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Raimund I. Herzog,

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Yanxia Li,

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯
Robert Sherwin

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America
⨯

Vaccination with Single Chain Antigen Receptors for Islet-Derived Peptides Presented on I-A^g7 Delays Diabetes in NOD Mice by Inducing Anergy in Self-Reactive T-Cells

Werner Gurr,
Margaret Shaw,
Raimund I. Herzog,
Yanxia Li,
Robert Sherwin

Published: July 24, 2013
https://doi.org/10.1371/journal.pone.0069464

About the Authors

Werner Gurr

* E-mail: werner.gurr@yale.edu

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

Margaret Shaw

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

Raimund I. Herzog

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

Yanxia Li

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

Robert Sherwin

Affiliation Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WG. Performed the experiments: WG MS YL. Analyzed the data: WG MS YL RS. Contributed reagents/materials/analysis tools: RIH. Wrote the paper: WG MS RS.

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T cells
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Cloning
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Vaccination and immunization
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T cell receptors
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Genetically modified animals
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Diabetes mellitus
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