About the Authors

Dorothy M. Jones-Davis

Contributed equally to this work with: Dorothy M. Jones-Davis, Mu Yang

Current address: American Association for the Advancement of Science Science and Technology Policy Fellow, The National Science Foundation, The Directorate for Engineering, Division of Engineering Education and Centers, Arlington, Virginia, United States of America

Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Mu Yang

Contributed equally to this work with: Dorothy M. Jones-Davis, Mu Yang

Current address: MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California, United States of America

Affiliation Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

Eric Rider

Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Nathan C. Osbun

Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Gilberto J. da Gente

Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Jiang Li

Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Adam M. Katz

Affiliation Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

Michael D. Weber

Affiliation Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

Saunak Sen

Affiliation Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

Jacqueline Crawley

Current address: MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California, United States of America

These authors also contributed equally to this work.

Affiliation Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America

Elliott H. Sherr

sherre@neuropeds.ucsf.edu

These authors also contributed equally to this work.

Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have the following interests. This work was funded in part by a grant from Pfizer, Inc. (http://www.pfizer.com) to Dr. Elliott Sherr. Dr. Mathew Pletcher (employed by Pfizer, Inc.) provided suggestions in the design and interpretation of the study, and Dr. Nicholas Brandon (employed by Pfizer, Inc.) provided a critical reading of the manuscript. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Revised the manuscript and approved the final version: DMJ-D MY ER NCO GJD JL AMK MDW SS JC EHS. Conceived and designed the experiments: DMJ-D MY NCO GJD SS JC EHS. Performed the experiments: DMJ-D MY ER NCO GJD JL AMK MDW SS. Analyzed the data: DMJ-D MY GJD SS. Contributed reagents/materials/analysis tools: GJD SS JC EHS. Wrote the paper: DJD MY SS JC EHS.