About the Authors

Matthew M. Cousins

Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

David Swan

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Craig A. Magaret

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Donald R. Hoover

Affiliation Department of Statistics and Biostatistics and Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, New Jersey, United States of America

Susan H. Eshleman

seshlem@jhmi.edu

Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

MMC has given a presentation at a meeting sponsored by Idaho Technology (manufacturer of the LightScanner platform and reagents designed specifically for HRM analysis). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MMC. Performed the experiments: MMC DS. Analyzed the data: MMC DS DRH. Contributed reagents/materials/analysis tools: MMC DS CAM SHE. Wrote the paper: MMC DS CAM DRH SHE. Wrote the code for the DivMelt package: DS. Designed DivMelt: MMC DS CAM. Developed HRM diversity assay methods: MMC.