About the Authors

Richard G. James

Contributed equally to this work with: Richard G. James, Kathryn C. Davidson, Katherine A. Bosch

Current address: Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, Seattle, Washington, United States of America

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Kathryn C. Davidson

Contributed equally to this work with: Richard G. James, Kathryn C. Davidson, Katherine A. Bosch

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Katherine A. Bosch

Contributed equally to this work with: Richard G. James, Kathryn C. Davidson, Katherine A. Bosch

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Travis L. Biechele

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Nicholas C. Robin

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Russell J. Taylor

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Michael B. Major

Affiliation Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, North Carolina, United States of America

Nathan D. Camp

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Kerry Fowler

Affiliation KWF Consulting, Seattle, Washington, United States of America

Timothy J. Martins

Affiliations Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Quellos High Throughput Screening Core, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Randall T. Moon

rtmoon@uw.edu

Affiliations Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

Competing Interests

The authors have read the journal’s policy and have the following conflicts: RTM is a co-founder of, and consultant with, FATE THERAPEUTICS, San Diego.

Author Contributions

Conceived and designed the experiments: RGJ KCD TLB NCR MBM NDC KWF RTM. Performed the experiments: RGJ KCD KAB NCR RJT TJM. Analyzed the data: RGJ KCD NCR KWF TJM. Contributed reagents/materials/analysis tools: TJM. Wrote the paper: RGJ KCD KWF RTM.