About the Authors

Steven N. Quayle

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Jennifer Y. Lee

Affiliations Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Lydia W T. Cheung

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

Li Ding

Affiliations The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

Ruprecht Wiedemeyer

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Robert W. Dewan

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Emmet Huang-Hobbs

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Li Zhuang

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Richard K. Wilson

Affiliations The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

Keith L. Ligon

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Gordon B. Mills

Affiliation Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

Lewis C. Cantley

Affiliations Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Lynda Chin

lchin@mdanderson.org

Current address: Department of Genomic Medicine and Institute for Applied Cancer Science, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SNQ JYL LWTC LD RKW GBM LCC LC. Performed the experiments: SNQ JYL LWTC LD RW RWD EH LZ. Analyzed the data: SNQ JYL LWTC LD RKW KLL GBM LCC LC. Wrote the paper: SNQ LC.