About the Authors

Sofia Zanin

Affiliation Department of Biomedical Sciences and National Research Council Institute of Neurosciences, University of Padova, Padova, Italy

Christian Borgo

Affiliation Department of Biomedical Sciences and National Research Council Institute of Neurosciences, University of Padova, Padova, Italy

Cristina Girardi

Affiliation Department of Biomedical Sciences and National Research Council Institute of Neurosciences, University of Padova, Padova, Italy

Sean E. O'Brien

Affiliation Cylene Pharmaceuticals, San Diego, California, United States of America

Yoshihiko Miyata

Affiliation Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

Lorenzo A. Pinna

Affiliations Department of Biomedical Sciences and National Research Council Institute of Neurosciences, University of Padova, Padova, Italy, Venetian Institute of Molecular Medicine, Padova, Italy

Arianna Donella-Deana

Affiliation Department of Biomedical Sciences and National Research Council Institute of Neurosciences, University of Padova, Padova, Italy

Maria Ruzzene

maria.ruzzene@unipd.it

Affiliations Department of Biomedical Sciences and National Research Council Institute of Neurosciences, University of Padova, Padova, Italy, Venetian Institute of Molecular Medicine, Padova, Italy

Competing Interests

SOB is currently employed by Cylene Pharmaceuticals which holds United States patents for CX-4945 (United States 7,956,064) and CX-5011 (United States 7,910,600). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The remaining authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MR ADD LAP. Performed the experiments: SZ CB CG. Analyzed the data: MR SZ CB CG ADD. Contributed reagents/materials/analysis tools: SOB YM. Wrote the paper: MR.